IMPEDIMENTS OF PAIN THERAPY - LESSONS FROM THE CANCER PAIN INITATIVE MECKLENBURG-VORPOMMERN
WolfDiemer. Th Theurer*, H. Wendlandt*, M Wendt*, Dept of Anaesthesiology and Intensive Care,
Pain Service, Emst-Montz-Amdt-Univ Hospital, D-17487 Greifswald, Germany
Aim of Investigation. Cancer pain initiative Mecklenburg-Vorpomrnem (MV) is a joint demonstration
project of the medical board MV and the pain service, sponsored by the Federal Minister of Health
It runs 1996-99 to improve outpatient cancer pain therapy and palliative treatment in cooperation
with general practitioners (gp's) and district nurses
Methods. A survey in 500 physicians was conducted 1997 (and 1999) in two regions. Mecklenburg and Vorpommem Quality management interventions in three counties of Vorpommem include information for professionals, patients, relatives about cancer pain therapy and palliative medicine, four quality circles (participants' 40 physicians, 12 nurses, exchange of experiences in interdisciplinary working
groups), a palliative-care team (pet) supports the health care professionals in cancer pain therapy and palliative medicine in the outpatients, documentation of pain treatment
Results 50,6% of the questionnaires were returned 50% of the gp's know the WHO-ladder
and 75,5% have prescription forms for strong opioids In more than half of the patients the gp's
wish to have a multidisciplmary cooperation to treat difficult pain patients The pet achieved
over 2150 contacts to more than 210 patients to optimize the pain therapy. In 46% of the patients
an increase of opioid dose could solve the problems, in 16% a change was made from parenteral
to noninvasive treatment and in 14% a step up in the WHO-ladder was necessary
Conclusion. A pet is able to improve cancer pain therapy and to avoid admission to the
hospital The additional interventions are suitable to implement WHO-guidelmes Negotiations were
started to continue this work after the end of the demonstration project in December 1999
Acknowledgments supported by Fed Minister of Health Grant FB 2-43332-50/12
DOES FEAR ABOUT "DRUG ADDICTION" INFLUENCE GERMAN PHYSICIANS TREATING PAIN IN CANCER PATIENTS?
G G Hanekop, M T Bautz*. A Miesner*, M Kriegler*, U Stemmetz*, A. Him*, A Strube, F B M Ensmk*,DeptofAnes-thesiology,
Emergency-Medicine and Intensive-Care, Georg-August-Univ, Robert-Koch-Strasse 40, D-37075 Goettingen,
Germany
Aim of Investigation Cancer pain treatment is considered to be insufficient worldwide According to Twycross (1982) this is at least partly due to the influence of so called "opioid-myths", with fear of inducing drug addiction being one of the most important myths We tried to evaluate the knowledge and attitudes on cancer pain treatment among physicians in Lower-Saxony, thereby investigating
some of these myths
Methods In order to improve the current situation of palliative ; medicine a project called "SUPPORT" (http://come.to/SUPPORT) E was initiated with approval by the local ethics committee Before starting the interventions a pre-survey was earned out in 1997 A questionnaire consisting of more than 50 items was sent out to a representative random sample of 400 practicing physicians,
which was returned by 267 (67%) In a special section of the questionnaire on attitudes and knowledge about drug addiction physicians had to respond on a 6-pomt scale (1 = fully agree . 6 = fully disagree) to the statement ,,As there is a risk of developing drug addiction, one has to be very careful when prescribing opioids " On the other hand physicians were asked to estimate the incidence of drug
addiction induced by use of strong opioids
Results Two thirds of the responders indicated, that they do not agree with the given
statement (1=6 7%, 2=9 7%, 3=11 6%, 4 = 8 2%, 5=21 0%, 6 = 36 7%, missing = 6 0%) However, only
about half of the answering physicians estimated correctly the true incidence of drug addiction
(incidence <1% = 49 2%, 1-20% = 13 5%, 21 -40% = 4 4%, 41 -60% = 5.2%, 61 -80% = 0 8%, 81 -99%
= 0 4%, 100% = 4 0%, missing = 22 6%)
Conclusions The fear about drug addiction seems to have no substantial influence on the
attitudes of physicians treating cancer patients in Lower-Saxony with respect to their pain treatment
behavior However, the physicians in this sample tend to overestimate the true risk ofopioid induced
drug addiction These incorrect beliefs might interfere with adequate prescription rates of opioids
Reference Twycross, R (1982) Acta Anaesthesiol Scand 74(Suppl) 83-90
Acknowledgment Sponsored by the German Ministry of Health (BMG) with federal grant number
FB 2-43332-50/11.
THE INFLUENCE OF "OPIOID-MYTHS" ON THE ATTITUDES OF GERMAN PHYSICIANS TREATING PAIN IN CANCER PATIENTS.
F B M. Ensmk*. M T. Bautz*. W Weyland, A Albrecht*,I Benken*, D Beck*, A Miesner*, G G Hanekop,
Dept of Anesthe-siology, Emergency-Medicine and Intensive-Care, Georg-August-Univ, Robert-Koch-Strasse
40, D-37075 Goettingen, Germany
Aim of Investigation Cancer pain treatment is considered to be insufficient worldwide
According to Twycross (1982) this is at least partly due to the influence of so called ,,opioid-myths"
We tried to evaluate the knowledge and attitudes on cancer pain treatment among physicians in
Lower-Saxony, thereby investigating the myth that prescription of morphine invariably indicates
no chance for curing the disease
Methods In order to improve the current situation of palliative medicine a project called
..SUPPORT" (http //come to/SUPPORT) was initiated with approval by the local ethics committee
Before starting the interventions a pre-survey was earned out in 1997 A questionnaire consisting
of more than 50 items was sent out to a representative random sample of 400 practicing physicians,
which was returned by 267 (67%) They had to respond on a 6-point scale (1 = fully agree 6 = fully
disagree) to the following two statements ,,Prescnption of strong opioids indicates that the only
remaining choice is palliative care as there is no chance of cure " (Statement A) and ,,Strong
opioids are an indispensable choice of treatment for cancer pain" (Statement B)
Results More than two thirds of the responders indicated, that they do not agree with
Statement A (1=5 6%, 2=5 6%, 3=12 7%, 4 = 13 5%, 5=13 1%, 6 = 42 7%, missing = 6 7%), whereas
the ma-jonty of responders does agree with Statement B (1 = 74 5%, 2 = 9 7%, 3=5 2%, 4 = 1 5%,
5=0 8%, 6 = 1.9%, missing = 6 4%)
Conclusions In the sample under investigation it is well accepted that strong opioids
should be prescnbed whenever they are needed Furthermore, the data suggest that there is no adverse
influence of the aforementioned myth on the use of morphine under these circumstances. However,
it seems that the official consumption rates of strong opioids in Germany do not correspond well
to these self-reported attitudes In fact these official figures suggest that opioid prescription
for cancer pain is still insufficient Reference' Twycross, R (1982) Acta Anaesthesiol Scand 74(Suppl):
83-90
Acknowledgment Sponsored by the German Ministry of Health (BMG) with federal grant number
FB 2-43332-50/11
CANCER PAIN RELIEF - KNOWLEDGE AND ATTITUDES OF GENERAL PRACTITIONERS
Romania Lupsa. Csongor Csiki*, Dept of Oncology, Medical Univ, Tg. Mures, Romania
Aim of Investigation We evaluated the knowledge and attitudes of GPs connected to the
cancer pain treatment with opioids and adjuvants for analgesic effect.
Methods 43 general practitioners who attended a one-day course on palliative care were
questioned We compared the answers before and after the course, and we expressed the results in
percentage
Results According to the opinion of most doctors, 79 06 (before) and 86 66% (after the
course), cancer pain is treatable Before the course, 39 5% of participants considered that opioids
have to be used for cancer pain treatment alone or associated with NSAI and adjuvants After the
course this percentage grew up to 80% Only 53 48% of GPs know the legislation on using opioids
Also, there is a lack of knowledge in side effects of morphine. All the participants agreed with
the importance of a course based on this topic
Conclusions General practitioners lack knowledge in cancer pain treatment, in using opioid
analgesics and other drugs for cancer pain relief We have to change the attitudes concerning cancer
pain management of doctors, nurses and other health care workers That is necessary because in
Romania there are not any hospices yet, or specially trained medical staff in this field
IS THANATOPHOBIA AN IMPEDIMENT TO OPIOID USE BY HOSPICE NURSES?
Joseph M. Memll. A. Dale, C. Stratton Hill, Ronald I Lonmor, Jack I Thomby, Sharon M. Weinstein
(SPON S Wemstem), Dept of Family and Community Medicine Baylor College of Medicine and The Univ
of Texas M D. Anderson Cancer Center Houston, TX.
Aim of Investigation: Because reluctance to prescnbe opioids (OP) often prevents pain
relief even in end-of-life patients, we investigated the relationship between thanatophobia (TP),
the desire to avoid terminally ill patients, and opiophobia (OP)
Methods. Measures for both OP (SIA 84) and TP (SIA 0 87) constructs were developed High
scorers on the OP measure believe that opiates should be reserved for terminally ill patients
High scorers on TP feel uncomfortable, helpless, or frustrated when providing end-of-life care
Hospice nurses (n=39) and senior medical students (SMS) (n=213) completed a 110-item survey that
included the OP and TP scales with a battery of personal and professional role traits
Results: (1) Higher TP scores predicted higher OP scores in hospice nurses (p< 01)
and SMS (p< 001) (2) Among hospice RNs, TP accounted for 24% ofOP's variance (3) Nonetheless,
hospice nurses scored lower on both OP and TP (p< 001). (4) Structural equation modeling using
LISREL 8 revealed that nurses' and medical students' mental models ofOP and TP differed (5) Hospice
RNs' OP was predicted primarily by TP and SMS' OP, by reliance on hi-tech medicine. (6) For the
hospice RNs, TP was predicted by higher scores on authontananism, TP for the SMS, by intolerance
to clinical uncertainty
Conclusions Hospice nurses' thanatophobia is the major predictor of their opiophobia Structural
equation modeling identified the personal traits that are the major sources of these caregivers'
angst With this information, better counseling strategies can be devised that should lead to improved
end-of-life care
A MODEL FOR DELIVERY OF CANCER PAIN RELIEF IN DEVELOPING COUNTRIES.
Dr M R Raiagopal* (SPON D E. Joranson) Prof ofAnesthesiol-ogy, Pain & Palliative Care Society
(PPCS), World Health Org Demonstration Project, Medical College and Hospitals, Calicut 673-008
INDIA
Aim of Investigation- Develop cost-effective cancer pain relief for rural population in
India.
Methods. 1) Impediments to cancer pain relief identified poor patient access to pain relief,
low awareness about cancer, pain, palliative care, fears of morphine, stringent morphine regulations,
2) PPCS (South Indian State ofKerala, 29 million) developed palliative care and pain relief program
with limited resources by operating out of existing hospitals to avoid costs of construction,
obtaining funds from non-governmental organizations, 3) Low cost palliative care provided by home
care service to large population, home visits made by physicians, nurses who tram and empower
families, volunteers to provide basic nursing care Coverage achieved using referral unit, out-reach
network of 11 satellite clinics, 4) Education aimed at the public, professionals and regulators
to improve awareness and remove fear of morphine, 5) Morphine regulations are being simplified
in cooperation with the Kerala State Government and WHO Collaborating Center, Univ of Wisconsin,
USA
Results. In 1998, 1400 late stage cancer patients received good quality pain relief regardless
of financial condition, using oral morphine supplied by PPCS, there was no shortage and no diversion
to illicit use
Conclusions. A large portion of pain due to cancer in third world can be relieved by using
existing resources, well trained staff, families and volunteers, and by working with government
to improve patient access to oral morphine
GLOBAL AVAILABILITY OF MORPHINE
David Joranson. Aaron Gilson, Karen Ryan, John Nelson, Pain & Policy Studies Group, Univ
of Wisconsin, World Health Organization Collaborating Center, 1900 Univ Ave, Madison, Wisconsin,
53705 USA
Aim of Investigation To 1) report global morphine consumption as one indicator of progress
to improve pain relief; 2) determine if countries' development status predicts morphine consumption,
3) determine if increased morphine use increases its abuse
Methods 1) updated morphine consumption data from the International Narcotics Control
Board will be presented graphically; 2) these data will be compared to each countries' Human Development
Index score, and 3) trends in morphine abuse statistics in the U S will be compared to medical
consumption
Results Significant increases in global morphine consumption have occurred since the publication
of the WHO Three-Step Analgesic Ladder. Most increases in morphine use have occurred in developed
countries, with recent increases in developing countries, however, a country's development status
continues to be highly predictive of its morphine consumption In the U S , morphine abuse has
been very low and stable for the last fifteen years, despite substantial increases in medical
use
Conclusions Although morphine is not the only opioid for cancer pain, it is the most widely
available and consumption data are easily accessible. Morphine availability is improving in the
developed world, while cancer patients in developing countries, comprising the majority of the
world's population of cancer patients, continue to have little access In the U S , it is clear
that significant increases in medical use of morphine have not affected its low and stable level
of abuse
OPIOID CONSUMPTION PROFILE OF THE SCANDINAVIAN COUNTRIES
Torben G Clausen, Multidisciphnary Pain Center, National Hospital, Tagensve) 18 B, DK.-2200 Copenhagen,
Denmark
Aim of Investigation' To make a survey of the opioid consumption (OC) profile of the Scandinavian
countries
Methods The OC was evaluated from the annual statistics on opi-oids, reported to The International
Control Board, WHO The observation period was 1976 96 The study included the Scandinavian countnes
and their consumption of morphine, methddone and pethidine An analysis for 1996, including all
opioids was performed The consumption of the vanous drugs is presented as equipotent analgetic
doses (EADD) per mill inhabitants
Results The Scandinavian countries increased their OC of morphine, methadone and pethidine
with 904% on average Sweden 1559%, Denmark 962%, Norway 632% and Finland 243% In 1996, the total
Danish OC exceeded 1 mill EADD, compared with Sweden (272 000), Norway (145 000) and Finland (51
000). The study revealed considerable discrepancies in OC compared with the WHO statistics
Conclusion Denmark is the most opioid consuming country in Scandinavia The total Swedish
and Finish OC comprised only 25% and 5% of the Danish opioid use, respectively These differences
in OC may reflect discrepancies in national legislations on opioid prescription, use of opioids
in cancer and non-cancer patients, myths or insufficient knowledge concerning opioids among the
prescnbers.
MYTHS AND DIFFICULTIES IN MORPHINE PRESCRIPTION ON ONCOLOGIC PAIN
Silva R. Correia D, Freitas D*, Femandes F*, Alves E*, Centro Hospitalar do Funchal, Madeira
Island, Portugal Introduction In oncological disease, pain is one of its most worrying and incapacitating
symptoms, being frequently necessary to prescribe morphine
Aims of investigation The authors analyzed the opioids' therapeutics in Madeira Island,
its myths and difficulties involved with dealing with this kind of analgesic drug
Methods After building-up a questionnaire, the authors tested its reliability (test/retest/reliability)
and validity (contents, construction and validity criteria) They applied it to two different professional
groups (Doctors and Nurses) in a universe of 350 individuals.
Results The authors obtained and analyzed 300 questionnaires and documented fears, difficulties
and inherent myths of morphine prescription, having also made a data statistic with these results
Conclusion. The authors concluded that fears and myths of morphine use are so important
and very significant on both analyzed professional groups and contribute to the difficulties in
prescribing these pharmacological products, with its inherent minor use A better education and
knowledge in both professional groups is necessary in order to dimmish or vanish the stigma of
morphine use
METHADONE MAINTENANCE PATIENTS WITH PAIN AND CHRONIC PAIN PATIENTS ON OPIOIDS: HOW DIFFERENT ARE THESE POPULATIONS?
Nathaniel P Katz. Jamce Kauffman, Edgar Ross, and Robert N Jamison, Depts of Anesthesia and Psychiatry,
Bngham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Aim of Investigation The aim of this study was to compare chronic pain patients at pain
centers who were taking opioids for pain and individuals with chronic pain at methadone maintenance
centers who have a substance abuse history
Methods and Results 217 patients at two pain centers and 248 participants at three
methadone maintenance centers were surveyed, 112 (50 2%) of the pain patients were taking opioids
and 152 (61 3%) methadone maintenance patients reported chronic pain Methadone maintenance patients
with pain reported significantly more health problems (p<0.01), more psychiatric disturbance
(p<0.05), more prescription and nonprescnption medication use (p<0 01), and greater disability
(p < 0 05) Methadone patients with pain had longer duration of pain and longer opioid history
with greater perceived tolerance The majority of these patients hac fear of addiction yet believed
that methadone was helpful for their pain
Conclusions Some chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain These results raise many questions about chronic-pain treatment policies and resources for chronic pain patients with a history of substance abuse
9th WORLD CONGRESS ON PAIN, 1999, Vienna, Austria, p.231 - 233
|